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Expression of Γ-IFN mRNA in bronchoalveolar lavage fluid correlates with early acute allograft rejection in lung transplant recipients by A Moudgil; A Bagga; M Toyoda; E Nicolaidou; SC Jordan; D Ross is a Medicine article available to read on EtoBox.

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Various cytokines are upregulated in acute allograft rejection (AR). Local production of Th‐1 cytokines is suggested to play a pathogenic role in AR, and Th‐2 cytokines in the development of allograft tolerance. The purpose of this study was to correlate the expression of Th‐1 [interleukin‐2 (IL‐2) and Γ‐interferon (Γ‐IFN)], and Th‐2 [interleukin‐10 (IL‐10)] cytokines in bronchoalveolar lavage (BAL) fluid with AR in lung transplant (LT) recipients. The role of Th‐1 dominance expressed as IgG2/IgG1 ratio in BAL in AR was also examined. The mRNA expression for IL‐2, Γ‐IFN and IL‐10 was examined in 64 BAL specimens from 23 LT recipients using reverse transcriptase‐polymerase chain reaction (RT‐PCR). IgG1 and IgG2 levels were measured in 55 BAL specimens by enzyme‐linked immunosorbent assay (ELISA). The expression of mRNA for these cytokines, and the ratio of IgG2/IgG1 was correlated with AR (early AR occurring within 3 months of transplant and late AR occurring after 3 months). Ten patients had 17 episodes of biopsy proven AR. Twelve episodes of AR (6 patients) occurred within the first 3 months of transplantation. In 5 patients, AR was diagnosed 4, 5, 6, 9 and 24 months post‐transpla

Who reads Expression of Γ-IFN mRNA in bronchoalveolar lavage fluid correlates with early acute allograft rejection in lung transplant recipients?

Author

A Moudgil; A Bagga; M Toyoda; E Nicolaidou; SC Jordan; D Ross

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0902-0063)

Published

1999

Language

EN

Field

Medicine (Health Sciences)