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Can I read Child maltreatment and hypothalamic-pituitary-adrenal axis functioning: A systematic review and meta-analysis on EtoBox?
Child maltreatment and hypothalamic-pituitary-adrenal axis functioning: A systematic review and meta-analysis by Selina Schär; Ines Mürner-Lavanchy; Stefanie J. Schmidt; Julian Koenig; Michael Kaess is a Neuroscience article available to read on EtoBox.
What is Child maltreatment and hypothalamic-pituitary-adrenal axis functioning: A systematic review and meta-analysis about?
Alterations in hypothalamic-pituitary-adrenal (HPA) axis and its effector hormone cortisol have been proposed as one possible mechanism linking child maltreatment experiences to health disparities. In this series of metaanalyses, we aimed to quantify the existing evidence on the effect of child maltreatment on various measures of HPA axis activity. The systematic literature search yielded 1,858 records, of which 87 studies (k = 132) were included. Using random-effects models, we found evidence for blunted cortisol stress reactivity in individuals exposed to child maltreatment. In contrast, no overall differences were found in any of the other HPA axis activity measures (including measures of daily activity, cortisol assessed in the context of pharmacological challenges and cumulative measures of cortisol secretion). The impact of several moderators (e.g., sex, psychopathology, study quality), the role of methodological shortcomings of existing studies, as well as potential directions for future research are discussed.
Who reads Child maltreatment and hypothalamic-pituitary-adrenal axis functioning: A systematic review and meta-analysis?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Selina Schär; Ines Mürner-Lavanchy; Stefanie J. Schmidt; Julian Koenig; Michael Kaess
- Publisher
- Elsevier BV
- Published
- 2022
- Language
- EN
- Field
- Neuroscience (Life Sciences)