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Central giant cell granuloma: A clinicopathological and immunohistochemical study of macrophages, blood vessels, lymphatic vessels and regulatory proteins by Vinicius Rio Verde Melo-Muniz; Fábio Daumas Nunes; Maria Cristina Teixeira Cangussu; Patrícia Ramos Cury; Flávia Caló Aquino Xavier; Roberto Almeida de Azevedo; Águida Cristina Gomes Henriques Leitão; Ludmila de Faro Valverde; Bráulio Carneiro Júnior; Jean Nunes dos Santos is a Medicine article available to read on EtoBox.
What is Central giant cell granuloma: A clinicopathological and immunohistochemical study of macrophages, blood vessels, lymphatic vessels and regulatory proteins about?
## Objective: This study seeks to investigate immunohistochemical parameters that could distinguish non-aggressive central giant cell granuloma (cgcg) from aggressive cgcg, two groups of lesions which differ in their clinical and radiographic features and prognosis. ## Material and methods: 12 cases of non-aggressive cgcg and 11 cases of aggressive cgcg were investigated and associated the immunohistochemical expression of macrophages (cd68 and cd163), blood vessels (cd34 and cd105), lymphatic vessels (d2-40) and regulator proteins (p63 and ki-67). clinical and radiographic features were also studied. ## Results: Associations between all proteins in non-aggressive and aggressive cgcg were not significant (p > 0.05). with respect to non-aggressive cgcg, there were no significant correlations, while in aggressive cgcg there was a significant positive correlation between cd68 and cd163 (p = 0.031), between cd34 and d2-40 proteins (p = 0.04), whereas a significant negative correlation was observed between cd105 and cd68 (p = 0.040). however, regardless of aggressiveness of cgcg, there was a significant positive correlation between cd68 and cd163 (p = 0,04). among the clinical and immun
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- Author
- Vinicius Rio Verde Melo-Muniz; Fábio Daumas Nunes; Maria Cristina Teixeira Cangussu; Patrícia Ramos Cury; Flávia Caló Aquino Xavier; Roberto Almeida de Azevedo; Águida Cristina Gomes Henriques Leitão; Ludmila de Faro Valverde; Bráulio Carneiro Júnior; Jean Nunes dos Santos
- Publisher
- Elsevier Science; Elsevier ; W. B. Saunders Co., Ltd.; Elsevier BV (ISSN 1532-8198)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)