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Can I read Complex Evolution of Orthologous and Paralogous Decarboxylase Genes on EtoBox?
Complex Evolution of Orthologous and Paralogous Decarboxylase Genes by L. E. Sáenz‐de‐Miera; F. J. Ayala is a Agricultural and Biological Sciences article available to read on EtoBox.
What is Complex Evolution of Orthologous and Paralogous Decarboxylase Genes about?
## Abstract The decarboxylases are involved in neurotransmitter synthesis in animals, and in pathways of secondary metabolism in plants. Different decarboxylase proteins are characterized for their different substrate specificities, but are encoded by homologous genes. We study, within a maximum‐likelihood framework, the evolutionary relationships among __dopa decarboxylase__ (__Ddc__), __histidine decarboxylase__ (__Hdc__) and __α‐methyldopa hypersensitive__ (__amd__) in animals, and __tryptophan decarboxylase__ (__Wdc__) and __tyrosine decarboxylase__ (__Ydc__) in plants. The evolutionary rates are heterogeneous. There are differences between paralogous genes in the same lineages: 4.13 × 10^−10^ nucleotide substitutions per site per year in mammalian __Ddc__ vs. 1.95 in __Hdc__; between orthologous genes in different lineages, 7.62 in dipteran __Ddc__ vs. 4.13 in mammalian __Ddc__; and very large temporal variations in some lineages, from 3.7 up to 54.9 in the __Drosophila Ddc__ lineage. Our results are inconsistent with the molecular clock hypothesis.
Who reads Complex Evolution of Orthologous and Paralogous Decarboxylase Genes?
It is typically read by researchers, students, and practitioners in Agricultural and Biological Sciences.
- Author
- L. E. Sáenz‐de‐Miera; F. J. Ayala
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley; Springer Science and Business Media LLC (ISSN 1010-061X)
- Published
- 2003
- Language
- EN
- Field
- Agricultural and Biological Sciences (Life Sciences)