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Can I read Prolonged Standard Treatment for Systemic Lupus Erythematosus Fails to Normalize the Secretion of Innate Immunity-related Chemokines on EtoBox?
Prolonged Standard Treatment for Systemic Lupus Erythematosus Fails to Normalize the Secretion of Innate Immunity-related Chemokines by Vega, Luisa; Barbado, Julia; Almansa, Raquel; González-Gallego, Rocío; Rico, Lucía; Jimeno, Antonio; Nocito, Mercedes; Ortiz de Lejarazu, RaÃol; Bermejo-Martin, Jesus F. is a Immunology and Microbiology article available to read on EtoBox.
What is Prolonged Standard Treatment for Systemic Lupus Erythematosus Fails to Normalize the Secretion of Innate Immunity-related Chemokines about?
The pathogenesis of systemic lupus erythematosus (SLE) is far from having been elucidated at the molecular level. Using a multiplex system, we profiled 18 immune mediators in the plasma from 57 patients with SLE. Thirteen of them showed mild to moderate disease activity, and 29 showed severe activity, based upon the SLEDAI score. Fifteen patients were in complete clinical remission. Those patients with active disease, and those in clinical remission had been undergoing immunomodulatory treatment for an average of 10.7 months and 19.2 months respectively at the time of the visit. Samples obtained from 10 healthy volunteers were used as control. Patients with active disease and those with inactive disease showed elevated levels of the chemoattractant proteins MCP-1/CCL2, MIP1-β/CCL4 and IL-8/CXCL8 as compared to the control (p < 0.05). This pattern of increased mediator levels was observed regardless of the immunomodulatory drug regimen received (non-steroidal anti-inflammatory, steroids or immunosuppressants), and of the degree of tissue damage. Patients with anticardiolipin antibodies (ACAs) showed significantly higher levels of IL-8 and MIP-1β than those with no ACAs. Levels of MC
Who reads Prolonged Standard Treatment for Systemic Lupus Erythematosus Fails to Normalize the Secretion of Innate Immunity-related Chemokines?
It is typically read by researchers, students, and practitioners in Immunology and Microbiology.
- Author
- Vega, Luisa; Barbado, Julia; Almansa, Raquel; González-Gallego, Rocío; Rico, Lucía; Jimeno, Antonio; Nocito, Mercedes; Ortiz de Lejarazu, RaÃol; Bermejo-Martin, Jesus F.
- Publisher
- John Libbey Eurotext (ISSN 1952-4005)
- Published
- 2010
- Language
- EN
- Field
- Immunology and Microbiology (Life Sciences)