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Relationship between Helicobacter pylori virulence factors and regulatory cytokines as predictors of clinical outcome by Carolina Serrano; Maria Ines Diaz; Alejandra Valdivia; Alex Godoy; Alfredo Peña; Antonio Rollan; Arturo Kirberg; Eduardo Hebel; Jaqueline Fierro; Gabriela Klapp; Alejandro Venegas; Paul R. Harris is a Medicine article available to read on EtoBox.

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Helicobacter pylori infection is highly prevalent in Chile (73%). Usually a minority of infected patients develops complications such as ulcers and gastric cancer that have been associated with the presence of virulence factors (cagA, vacA) and host T helper response (Th1/Th2). Our aim was to evaluate the relationship between strain virulence and host immune response, using a multiple regression approach for the development of a model based on data collected from H. pylori infected patients in Chile. We analyzed levels of selected cytokines determined by ELISA (interleukin (IL)-12, IL-10, interferon (IFN)-gamma and IL-4) and the presence of cagA and vacA alleles polymorphisms determined by PCR in antral biopsies of 41 patients referred to endoscopy. By multiple regression analysis we established a correlation between bacterial and host factors using clinical outcome (gastritis and duodenal ulcer) as dependent variables. The selected model was described by: clinical outcome=0.867491 (cagA)+0.0131847 (IL-12/IL-10)+0.0103503 (IFN-gamma/IL-4) and it was able to explain over 90% of clinical outcomes observations (R(2)=96.4). This model considers that clinical outcomes are better explain

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Author

Carolina Serrano; Maria Ines Diaz; Alejandra Valdivia; Alex Godoy; Alfredo Peña; Antonio Rollan; Arturo Kirberg; Eduardo Hebel; Jaqueline Fierro; Gabriela Klapp; Alejandro Venegas; Paul R. Harris

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 1286-4579)

Published

2007

Language

EN

Field

Medicine (Life Sciences)