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Can I read Interferon induces proliferation in leukemic and normal B-cell subsets on EtoBox?
Interferon induces proliferation in leukemic and normal B-cell subsets by Dr. Karl-Henrik Robért; Stefan Einhorn; Leif Östlund; Gunnar Juliusson; Peter Biberfeld is a Medicine article available to read on EtoBox.
What is Interferon induces proliferation in leukemic and normal B-cell subsets about?
3H-thymidine incorporation following stimulation with interferon (IFN) in vitro was investigated in cell cultures from peripheral blood of patients with chronic lymphocytic leukemia (CLL), spleens from necro-kidney transplants and healthy blood donors. It was demonstrated, that IFN can induce a proliferative response in some normal as well as leukemic B lymphocyte subsets. The responses were not T-cell dependant. The results indicate, that B-cell subsets that proliferate in the presence of IFN, are present in higher proportions in spleen than in peripheral blood, and that they constitute a portion of the leukemic blood lymphocyte pool in some patients with CLL. We have previously demonstrated, that IFN induces varying degrees of transformation and differentiation in blood lymphocytes from a majority of CLL patients. The functional characteristics of different B-cell subsets, and their heterogenous distribution in leukemia, may be important for the results of IFN treatment in various malignant B-cell disorders.
Who reads Interferon induces proliferation in leukemic and normal B-cell subsets?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Dr. Karl-Henrik Robért; Stefan Einhorn; Leif Östlund; Gunnar Juliusson; Peter Biberfeld
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0278-0232)
- Published
- 1986
- Language
- EN
- Field
- Medicine (Health Sciences)