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The C-X-C chemokine Mig is highly expressed in the papillae of psoriatic lesions by Matthias Goebeler; Atiye Toksoy; Ullrich Spandau; Eva Engelhardt; Eva-Bettina Bröcker; Reinhard Gillitzer is a Medicine article available to read on EtoBox.

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A prominent feature within the histopathological changes of psoriatic lesions is the particular spatial distribution of neutrophils, macrophages, and T-cells which are considered to participate in the pathogenesis of psoriasis. In this study, an attempt has been made to examine the microanatomical localization and magnitude of expression of the T-cell-attractant and -stimulating C-X-C and C-C chemokines Mig, interferon-inducible protein-10 (IP-10), macrophage inflammatory protein-1 and 1 (MIP-1 and -1 ), and regulated on activation, normal T-cell expressed and secreted (RANTES). Employing in situ hybridization, Mig message was strongly and selectively expressed in the upper lesional dermis with pronounced clustering in the tips of the papillae, whereas expression in normal or uninvolved skin was quiescent. In contrast, message for all the other chemokines investigated was much weaker or lacking. Expression of Mig transcripts in cell clusters of the papillae was paralleled by Mig immunoreactivity on endothelial and mononuclear cells. The expression profile, with high levels of Mig virtually limited to those lesional papillae with a pronounced infiltration of mononuclear leukocytes,

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Author

Matthias Goebeler; Atiye Toksoy; Ullrich Spandau; Eva Engelhardt; Eva-Bettina Bröcker; Reinhard Gillitzer

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0022-3417)

Published

1998

Language

EN

Field

Medicine (Health Sciences)