Can I read +331G/A variant in the progesterone receptor gene, postmenopausal hormone use and risk of breast cancer on EtoBox?

+331G/A variant in the progesterone receptor gene, postmenopausal hormone use and risk of breast cancer by Joanne Kotsopoulos; Shelley S. Tworoger; Immaculata DeVivo; Susan E. Hankinson; David J. Hunter; Walter C. Willett; Wendy Y. Chen is a Medicine article available to read on EtoBox.

What is +331G/A variant in the progesterone receptor gene, postmenopausal hormone use and risk of breast cancer about?

## Abstract A functional promoter polymorphism in the progesterone receptor (__PR__) gene previously has been associated with an increased risk of postmenopausal breast cancer. Whether the relationship between genetic variation in __PR__ and risk of breast cancer is modified by postmenopausal hormone (PMH) use is unknown. Thus, we conducted a case–control study nested within the prospective Nurses' Health Study to evaluate if the risk of breast cancer associated with having the +__331 A__ risk allele was modified by PMH use. Genotyping of this SNP was available for 1,664 postmenopausal breast cancer cases and 2,391 controls. Logistic regression was used to estimate the odds ratios (ORs) and 95% confidence intervals (CIs) for breast cancer. Women who were carriers of 1 or both variant __A__ alleles had a 31% increased risk of developing breast cancer (95% CI 1.04–1.65). PMH use significantly modified the association between the +__331G__/__A__ polymorphism and risk (__p__‐interaction <0.05). Among never users of PMH, women who were variant carriers had a significantly increased risk of breast cancer compared to those with the wild‐type genotype (OR = 2.57; 95% CI 1.64–4.02). The +__

Who reads +331G/A variant in the progesterone receptor gene, postmenopausal hormone use and risk of breast cancer?

Author

Joanne Kotsopoulos; Shelley S. Tworoger; Immaculata DeVivo; Susan E. Hankinson; David J. Hunter; Walter C. Willett; Wendy Y. Chen

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)

Published

2009

Language

EN

Field

Medicine (Health Sciences)