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Molecular and epidemiologic characterization of the diphtheria outbreak in Venezuela by Strauss, Ricardo A. (author);Herrera-Leon, Laura (author);Guillén, Ana C. (author);Castro, Julio S. (author);Lorenz, Eva (author);Carvajal, Ana (author);Hernandez, Elizabeth (author);Navas, Trina (author);Vielma, Silvana (author);Lopez, Neiris (author);Lopez, Maria G. (author);Aurenty, Lisbeth (author);Navas, Valeria (author);Rosas, Maria A. (author);Drummond, Tatiana (author);Martínez, José G. (author);Hernández, Erick (author);Bertuglia, Francis (author);Andrade, Omaira (author);Torres, Jaime (author);May, Jürgen (author);Herrera-Leon, Silvia (author);Eibach, Daniel (author) is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Molecular and epidemiologic characterization of the diphtheria outbreak in Venezuela about?

In 2016, Venezuela faced a large diphtheria outbreak that extended until 2019. Nasopharyngeal or oropharyngeal samples were prospectively collected from 51 suspected cases and retrospective data from 348 clinical records was retrieved from 14 hospitals between November 2017 and November 2018. Confirmed pathogenic Corynebactrium isolates were biotyped. Multilocus Sequence Typing (MLST) was performed followed by next-generation-based core genome-MLST and minimum spanning trees were generated. Subjects between 10 and 19 years of age were mostly affected (n = 95; 27.3%). Case fatality rates (CFR) were higher in males (19.4%), as compared to females (15.8%). The highest CFR (31.1%) was observed among those under 5, followed by the 40 to 49 age-group (25.0%). Nine samples corresponded to C. diphtheriae and 1 to C. ulcerans. Two Sequencing Types (ST), ST174 and ST697 (the latter not previously described) were identified among the eight C. diphtheriae isolates from Carabobo state. Cg-MLST revealed only one cluster also from Carabobo. The Whole Genome Sequencing analysis revealed that the outbreak seemed to be caused by different strains with C. diphtheriae and C. ulcerans coexisting. The r

Who reads Molecular and epidemiologic characterization of the diphtheria outbreak in Venezuela?

It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.

Author
Strauss, Ricardo A. (author);Herrera-Leon, Laura (author);Guillén, Ana C. (author);Castro, Julio S. (author);Lorenz, Eva (author);Carvajal, Ana (author);Hernandez, Elizabeth (author);Navas, Trina (author);Vielma, Silvana (author);Lopez, Neiris (author);Lopez, Maria G. (author);Aurenty, Lisbeth (author);Navas, Valeria (author);Rosas, Maria A. (author);Drummond, Tatiana (author);Martínez, José G. (author);Hernández, Erick (author);Bertuglia, Francis (author);Andrade, Omaira (author);Torres, Jaime (author);May, Jürgen (author);Herrera-Leon, Silvia (author);Eibach, Daniel (author)
Publisher
Springer Science and Business Media LLC
Published
2021
Language
EN
Field
Biochemistry, Genetics and Molecular Biology (Life Sciences)

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Browse all works by Strauss, Ricardo A. (author);Herrera-Leon, Laura (author);Guillén, Ana C. (author);Castro, Julio S. (author);Lorenz, Eva (author);Carvajal, Ana (author);Hernandez, Elizabeth (author);Navas, Trina (author);Vielma, Silvana (author);Lopez, Neiris (author);Lopez, Maria G. (author);Aurenty, Lisbeth (author);Navas, Valeria (author);Rosas, Maria A. (author);Drummond, Tatiana (author);Martínez, José G. (author);Hernández, Erick (author);Bertuglia, Francis (author);Andrade, Omaira (author);Torres, Jaime (author);May, Jürgen (author);Herrera-Leon, Silvia (author);Eibach, Daniel (author)