Can I read Downregulation of XIAP expression in ovarian cancer cells induces cell death \ \ in vitro\ \ and \ \ in vivo\ \ on EtoBox?

Downregulation of XIAP expression in ovarian cancer cells induces cell death \ \ in vitro\ \ and \ \ in vivo\ \ by Tanya J. Shaw; Eric C. Lacasse; Jon P. Durkin; Barbara C. Vanderhyden is a Medicine article available to read on EtoBox.

What is Downregulation of XIAP expression in ovarian cancer cells induces cell death \ \ in vitro\ \ and \ \ in vivo\ \ about?

## Abstract A hallmark of cancer cells is an ability to evade apoptosis. Overexpression and/or activating mutations of prosurvival molecules such as the X‐linked inhibitor of apoptosis (XIAP) contribute to this inappropriate cell survival. Our objectives were to investigate the effects of downregulation of XIAP in ovarian cancer cells __in vitro__ and __in vivo__ using the clinical candidate antisense oligonucleotide against XIAP, AEG35156 (AS XIAP). Three ovarian cancer cell lines were transfected with AS XIAP __in vitro__, and the effects on cell survival were assessed. Downregulation of XIAP resulted in significant apoptosis. To investigate the __in vivo__ efficacy of AS XIAP, CD‐1 nude mice were xenografted intraperitoneally with A2780‐cp cells, treated with intraperitoneal AS XIAP and evaluated for survival time and tumor histology. Mice treated with 10 mg/kg/day AS XIAP showed a significant improvement in survival time compared to animals treated with control oligonucleotides. Histological analysis of the tumors showed significantly fewer viable cells in the AS XIAP‐treated tumors. Downregulation of XIAP expression in ovarian cancer cells resulted in apoptosis __in vitro__ an

Who reads Downregulation of XIAP expression in ovarian cancer cells induces cell death \ \ in vitro\ \ and \ \ in vivo\ \?

Author

Tanya J. Shaw; Eric C. Lacasse; Jon P. Durkin; Barbara C. Vanderhyden

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)

Published

2007

Language

EN

Field

Medicine (Health Sciences)