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Muscle Mass and Function in Thyrotoxic Patients Before and During Medical Treatment by Helene Nørrelund; Karen Yde Hove; Eva Brems-Dalgaard; Anne Grethe Jurik; Lars Peter Nielsen; Søren Nielsen; Steen Nielsen; Jens Otto Lunde Jørgensen; Jørgen Weeke; Niels Møller is a Medicine article available to read on EtoBox.

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## OBJECTIVE Development of muscle weakness and atrophy are well known complications of thyrotoxicosis, although little is known about its clinical course. The present longitudinal study was therefore undertaken to monitor muscle mass and strength before and during treatment of hyperthyroidism. ## DESIGN AND PATIENTS Five patients (2 male, 3 female; Age 41 ± 6 years; BMI 22.2 ± 1.1 kg/m^2^) with newly diagnosed hyperthyroidism were studied with respect to muscle area, muscle strength, body composition and substrate metabolism at baseline and after 1, 3, 6, 9 and 12 months of treatment. ## MEASUREMENTS Midthigh muscle areas were assessed by computed tomography (CT), while bioelectrical impedance analysis (BIA) was used for assessment of body composition. The isometric strength of the biceps brachialis and quadriceps muscles was assessed by means of a dynamometer and the maximal static ins‐ and ex‐piratory mouth pressures were measured with a respiratory pressure module. ## RESULTS Prior to treatment thyrotoxic patients all displayed elevated levels of total and free T~3~ and T~4~ together with suppressed TSH. BMI, fat mass and lean body mass increased significantly during the treatm

Who reads Muscle Mass and Function in Thyrotoxic Patients Before and During Medical Treatment?

Author

Helene Nørrelund; Karen Yde Hove; Eva Brems-Dalgaard; Anne Grethe Jurik; Lars Peter Nielsen; Søren Nielsen; Steen Nielsen; Jens Otto Lunde Jørgensen; Jørgen Weeke; Niels Møller

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley; Research Square (ISSN 0300-0664)

Published

1999

Language

EN

Field

Medicine (Health Sciences)