About this Medicine article

Obstetrical and neonatal outcomes after benzodiazepine exposure during pregnancy: Results from a prospective registry of women with psychiatric disorders by Freeman, Marlene P.; Góez-Mogollón, Lina; McInerney, Kathryn A.; Davies, Abigail C.; Church, Taylor R.; Sosinsky, Alexandra Z.; Noe, Olivia B.; Viguera, Adele C.; Cohen, Lee S. is a Medicine article available to read on EtoBox.

## Objective: The goal of this analysis was to examine the effect of benzodiazepine use during pregnancy on maternal and neonatal outcomes in a cohort of women with psychiatric disorders. ## Methods: 794 evaluable women from the massachusetts general hospital national pregnancy registry for psychiatric medications were followed across pregnancy (n = 144 exposed to benzodiazepines and n = 650 unexposed). data obtained through maternal report and medical records included maternal outcomes (cesarean section, preeclampsia) and neonatal outcomes (birth weight, breathing difficulty, feeding difficulty, head circumference, 5-minute apgar score, muscular and/or extrapyramidal symptoms, nicu admission, prematurity). ## Results: In adjusted analyses, infants exposed to benzodiazepines in utero were more likely to be admitted to the nicu (or: 2.02, 95% ci: 1.11, 3.66) and to have small head circumferences (or: 3.89, 95% ci: 1.25, 12.03) compared to unexposed infants. other neonatal adverse effects such as respiratory distress or muscular symptoms including hypotonia were not observed. there were no significant differences in adverse obstetrical outcomes. ## Conclusions: Infants exposed to ben

Author

Freeman, Marlene P.; Góez-Mogollón, Lina; McInerney, Kathryn A.; Davies, Abigail C.; Church, Taylor R.; Sosinsky, Alexandra Z.; Noe, Olivia B.; Viguera, Adele C.; Cohen, Lee S.

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0163-8343)

Published

2018

Language

EN

Field

Medicine (Health Sciences)