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Penetration and Effect of Topically Applied Dimethylsulfoxide or Indomethacin on Adjuvant Arthritis in the Rat by Dr Marion D. Francis; Patricia A. Horn; Lionel D. Mccreary is a Medicine article available to read on EtoBox.

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## Abstract The present study, using ^14^C‐DMSO, established the systemic and local load and distribution of topically applied DMSO in adjuvant arthritic rats. Under equivalent conditions, the antiinflammatory effects (systemic and local) of topical DMSO treatments were compared with a topical treatment of a control vehicle or of indomethacin, a known effective antiinflammatory agent. No significant systemic or local antiinflammatory effect of topical DMSO was seen in the adjuvant arthritic rats. Indomethacin, applied topically, had a significant systemic antiinflammatory effect; however, no significant local antiinflammatory effect of indomethacin was observed.

Who reads Penetration and Effect of Topically Applied Dimethylsulfoxide or Indomethacin on Adjuvant Arthritis in the Rat?

Author

Dr Marion D. Francis; Patricia A. Horn; Lionel D. Mccreary

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0004-3591)

Published

1983

Language

EN

Field

Medicine (Health Sciences)