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Association of cardiac and vascular changes with ambient PM2.5 in diabetic individuals by Alexandra Schneider; Lucas M Neas; Don W Graff; Margaret C Herbst; Wayne E Cascio; Mike T Schmitt; John B Buse; Annette Peters; Robert B Devlin is a Environmental Science article available to read on EtoBox.

What is Association of cardiac and vascular changes with ambient PM2.5 in diabetic individuals about?

Background and Objective: Exposure to fine airborne particles (PM 2.5 ) has been shown to be responsible for cardiovascular and hematological effects, especially in older people with cardiovascular disease. Some epidemiological studies suggest that individuals with diabetes may be a particularly susceptible population. This study examined effects of short-term exposures to ambient PM 2.5 on markers of systemic inflammation, coagulation, autonomic control of heart rate, and repolarization in 22 adults (mean age: 61 years) with type 2 diabetes. Methods: Each individual was studied for four consecutive days with daily assessments of plasma levels of blood markers. Cardiac rhythm and electrocardiographic parameters were examined at rest and with 24-hour ambulatory ECG monitors. PM 2.5 and meteorological data were measured daily on the rooftop of the patient exam site. Data were analyzed with models adjusting for season, weekday, meteorology, and a random intercept. To identify susceptible subgroups, effect modification was analyzed by clinical characteristics associated with insulin resistance as well as with oxidative stress and by medication intake. Results: Interleukin (IL)-6 and tu

Who reads Association of cardiac and vascular changes with ambient PM2.5 in diabetic individuals?

Author

Alexandra Schneider; Lucas M Neas; Don W Graff; Margaret C Herbst; Wayne E Cascio; Mike T Schmitt; John B Buse; Annette Peters; Robert B Devlin

Publisher

BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2004-; Springer Science and Business Media LLC (ISSN 1743-8977)

Published

2010

Language

EN

Field

Environmental Science (Physical Sciences)