Can I read Diversifying selective pressure on influenza B virus hemagglutinin on EtoBox?

Diversifying selective pressure on influenza B virus hemagglutinin by Jun Shen; Brian D. Kirk; Jianpeng Ma; Qinghua Wang is a Medicine article available to read on EtoBox.

What is Diversifying selective pressure on influenza B virus hemagglutinin about?

## Abstract Influenza B virus hemagglutinin (HA) is a major surface glycoprotein with frequent amino acid substitutions. However, the roles of antibody selection in the amino acid substitutions of HA were still poorly understood. In order to gain insights into this important issue, an analysis was conducted on a total of 271 HA~1~ sequences of influenza B virus strains isolated during 1940–2007. In this analysis, phylogenetic analysis by maximum likelihood (PAML) package was used to detect the existence of positive selection and to identify positively selected sites on HA~1~. Strikingly, all the positively selected sites were located in the four major epitopes (120‐loop, 150‐loop, 160‐loop, and 190‐helix) of HA identified in previous studies, thus supporting a predominant role of antibody selection in HA evolution. Of particular significance is the involvement of the 120‐loop in positive selection, which may become increasingly important in future field isolates. Despite the absence of different subtypes, influenza B virus HA continued to evolve into new sublineages, within which the four major epitopes were targeted selectively in positive selection. Thus, any newly emerging strai

Who reads Diversifying selective pressure on influenza B virus hemagglutinin?

Author

Jun Shen; Brian D. Kirk; Jianpeng Ma; Qinghua Wang

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0146-6615)

Published

2008

Language

EN

Field

Medicine (Health Sciences)