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Hemorrhagic Shock Resuscitation with Carbon Monoxide Saturated Blood by Pedro Cabrales; Amy G. Tsai; Marcos Intaglietta is a Medicine article available to read on EtoBox.

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The response to exchange transfusion with red blood cells (RBCs) saturated with carbon monoxide (CO) in amelioration of microvascular function and providing tissue protection in hemorrhagic shock resuscitation was investigated in the hamster chamber window model. Shock was induced by the withdrawal of 50% of blood volume (BV). Blood volume was restored 1 h after hemorrhage with a single volume infusion (resuscitation) of 25% BV with fresh RBCs (saturated or unsaturated with CO) suspended in human serum albumin (HSA). Hemorrhage, shock and resuscitation were monitored continuously in terms of mean arterial pressure (MAP), microvascular blood flow, capillary perfusion and systemic gas parameters. Eight hours after resuscitation, Annexin V and propidium iodide (PI) were injected into the window chamber to study tissue viability, and labeled cells were observed by using intravital epifluorescence microscopy. TUNEL staining was performed on the tissue to confirm in vivo results. Systemic and microvascular restoration were not different with or without CO up to 90 min after resuscitation. CO concentration decreased over 90 min, increasing oxygen carrying capacity and gradually reoxygenat

Who reads Hemorrhagic Shock Resuscitation with Carbon Monoxide Saturated Blood?

Author

Pedro Cabrales; Amy G. Tsai; Marcos Intaglietta

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0300-9572)

Published

2007

Language

EN

Field

Medicine (Health Sciences)