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Long and Short-Term Effect of mTOR Regulation on Cerebral Organoid Growth and Differentiations by Sung Bum Park; Byungho Lim; Ki Young Kim; Byumseok Koh is a Medicine article available to read on EtoBox.

What is Long and Short-Term Effect of mTOR Regulation on Cerebral Organoid Growth and Differentiations about?

BACKGROUND The mammalian target of rapamycin (mTOR) signaling is critical for the maintenance and differentiation of neurogenesis, and conceivably for many other brain developmental processes. However, in vivo studies of mTOR functions in the brain are often hampered due to the essential role of the associated signaling in brain development. METHODS We monitored the long-and short-term effects of mTOR signaling regulation on cerebral organoids growth, differentiation and function using an mTOR inhibitor (everolimus) and an mTOR activator (MHY1485). RESULTS Short-term treatment with MHY1485 induced faster organoid growth and differentiation, while long-term treatment induced the maturation of cerebral organoids. CONCLUSION These data suggest that the optimal activity of mTOR is crucial in maintaining normal brain development, and its role is not confined to the early neurogenic phase of brain development.

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Author

Sung Bum Park; Byungho Lim; Ki Young Kim; Byumseok Koh

Publisher

Springer Science and Business Media LLC

Published

2023

Language

EN

Field

Medicine (Health Sciences)