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Patients Can Expect Long-term Satisfaction after Prostate Brachytherapy by M. Zhang; M.F. Munsell; D.A. Swanson; R.J. Kudchadker; J.M. Albert; D.L. Urbauer; D.A. Kuban; T.L. Bruno; S.J. Frank is a Medicine article available to read on EtoBox.

What is Patients Can Expect Long-term Satisfaction after Prostate Brachytherapy about?

Purpose/Objective(s): We report a comparative analysis of 5-year clinical outcome in patients with Gleason 7 prostate cancer following definitive radiation therapy with dose escalation irradiation using CT-based offline image-guided adaptive radiation therapy (IGRT) technique or a brachytherapy (IGBT) implant as monotherapy. Materials/Methods: From 7/95-7/09, 335 patients with Gleason 7 (3 + 4) prostate cancer were treated with IGRT (n = 246) or IGBT [(n = 89); 78 HDR (High dose rate)/11Pd (Palladium)]. Patients with Gleason 7 (4 + 3) were excluded from this analysis. All treatments were delivered according to prospective HIC-approved protocols. IGRT was performed using a CT-based offline adaptive protocol with the creation of patient-specific confidence-limited planning target volumes (cl-PTV). Using 3D-CRT or IMRT, the median dose for IGRT was 75.6 Gy (70.2 -82.3 Gy). Brachytherapy was performed via interstitial implant. HDR was delivered in 4 fractions of 9.5 Gy each (38 Gy) or 2 fractions of 12 Gy each (24 Gy), with a median dose of 38.0 Gy (24.0 -38.0 Gy). Pd dose was 120 Gy. Clinical outcomes were measured and biochemical control was reported as defined by the Phoenix definit

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Author

M. Zhang; M.F. Munsell; D.A. Swanson; R.J. Kudchadker; J.M. Albert; D.L. Urbauer; D.A. Kuban; T.L. Bruno; S.J. Frank

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)

Published

2010

Language

EN

Field

Medicine (Health Sciences)