Can I read A Fiber Optoacoustic Emitter with Maximized Conversion Efficiency and Controlled Ultrasound Frequency for Biomedical Applications on EtoBox?

A Fiber Optoacoustic Emitter with Maximized Conversion Efficiency and Controlled Ultrasound Frequency for Biomedical Applications by Shi, Linli; Jiang, Ying; Zhang, Yi; Lan, Lu; Huang, Yimin; Cheng, Ji-Xin; Yang, Chen is a scholarly article available to read on EtoBox.

What is A Fiber Optoacoustic Emitter with Maximized Conversion Efficiency and Controlled Ultrasound Frequency for Biomedical Applications about?

Focused ultrasound has attracted great attention in minimally invasive therapy, gene delivery, brain stimulation, etc. Frequency below 1 MHz has been identified preferable for high-efficacy drug delivery, gene transfection and neurostimulation due to minimized tissue heating and cell fragmentation. However, the poor spatial resolution of several millimeters and the large device diameter of ~25 mm of current sub-MHz ultrasound technology severely hinders its further applications for effective, precise, safe and wearable biomedical studies and clinical use. To address this issue, we report the development of a novel fiber-based optoacoustic emitter (FOE). The FOE, a new miniaturized ultrasound source, is composed of an optical diffusion coating layer and an expansion coating layer at an optical fiber distal end with a diameter of approximately 500 microns. Taking advantage of the fiber size and diffusive nanoparticles introduced, the ultrasound generated by the FOEs showed a spatial confinement of sub-millimeter. The optoacoustic conversion efficiency was maximized through choosing absorbing nanomaterials and thermal expansion matrix. Controllable frequencies in the range of 0.083 MH

Author

Shi, Linli; Jiang, Ying; Zhang, Yi; Lan, Lu; Huang, Yimin; Cheng, Ji-Xin; Yang, Chen

Published

2019

Language

EN