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The effect of vitamin E on stress-induced changes in visual evoked potentials (VEPs) in rats exposed to different experimental stress models by Piraye Yargiçoğlu; Nazmi Yaraş; Aysel Ağar; Saadet Gümüşlü; Süreyya Bilmen; Gül Özkaya is a Medicine article available to read on EtoBox.
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## Purpose: The aim of the study was to investigate the effects of vitamin e on stress-induced changes in visual evoked potentials (veps) and lipid peroxidation. ## Methods: Eight experimental groups of 10 rats per group were formed. these consisted of the control group (c); the group treated with vitamin e (e); groups exposed to cold stress (cs), immobilization stress (is) and both cold and immobilization stress (cis), and groups exposed to equivalent stresses and treated with vitamin e (cse, ise, cise). vitamin e was injected intramuscularly in a dose of 30 mg/kg/day. ## Results: Following chronic stress (15 days), plasma corticosterone concentrations in all experimental groups were significantly increased over those in c group. vitamin e significantly decreased corticosterone levels in all stress groups compared with their respective control groups. brain nitrite levels were significantly more elevated in all stress groups than in the c group. vitamin e reduced retina and brain nitrite levels in all stress and e groups compared with their respective control groups. vitamin e decreased glutathione peroxidase (gsh-px) activity in retina and brain tissues in the cse group, but incr
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- Author
- Piraye Yargiçoğlu; Nazmi Yaraş; Aysel Ağar; Saadet Gümüşlü; Süreyya Bilmen; Gül Özkaya
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 1395-3907)
- Published
- 2003
- Language
- EN
- Field
- Medicine (Health Sciences)