Opening book details…
Can I read Convergent Deployment of Ancestral Functions During the Evolution of Mammalian Flight Membranes on EtoBox?
Convergent Deployment of Ancestral Functions During the Evolution of Mammalian Flight Membranes by Charles Y. Feigin; Jorge A. Moreno; Raul Ramos; Sarah A. Mereby; Ares Alivisatos; Wei Wang; Renée van Amerongen; Jasmin Camacho; John J. Rasweiler; Richard R. Behringer; Bruce Ostrow; Maksim V. Plikus; Ricardo Mallarino is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Convergent Deployment of Ancestral Functions During the Evolution of Mammalian Flight Membranes about?
Lateral flight membranes, or patagia, have evolved repeatedly in diverse mammalian lineages. While little is known about patagium development, its recurrent evolution may suggest a shared molecular basis. By combining transcriptomics, developmental experiments, and mouse transgenics, we demonstrate that lateral __Wnt5a__ expression in the marsupial sugar glider (__Petaurus breviceps__) promotes the differentiation of its patagium primordium. We further show that this function of __Wnt5a__ reprises ancestral roles in skin morphogenesis predating mammalian flight and has been convergently used during patagium evolution in eutherian bats. Moreover, we find that many genes involved in limb development have been redeployed during patagium outgrowth in both the sugar glider and bat. Together, our findings reveal that deeply conserved genetic toolkits contribute to the evolutionary transition to flight in mammals.
Who reads Convergent Deployment of Ancestral Functions During the Evolution of Mammalian Flight Membranes?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Charles Y. Feigin; Jorge A. Moreno; Raul Ramos; Sarah A. Mereby; Ares Alivisatos; Wei Wang; Renée van Amerongen; Jasmin Camacho; John J. Rasweiler; Richard R. Behringer; Bruce Ostrow; Maksim V. Plikus; Ricardo Mallarino
- Publisher
- American Association for the Advancement of Science
- Published
- 2023
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Physical Sciences)