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Can I read Design of an Integrated Optics for Transglutaminase Conformational Change on EtoBox?
Design of an Integrated Optics for Transglutaminase Conformational Change by Chen Chen; Xun Hou; Jinhai Si is a Engineering article available to read on EtoBox.
What is Design of an Integrated Optics for Transglutaminase Conformational Change about?
A detailed theoretical research on a novel integrated optics with surface plasmon resonance (SPR)based waveguide is presented. An SPR multilayer section is designed by introducing intermediate layers to support fundamental mode and stronger electromagnetic field. Most current techniques excited with a single optical mode are "blind" to the conformational change of bound molecules. The greatest strength of such technique lies in monitoring protein conformational change. The Mach-Zehnder interferometry architecture is adopted to maximize sensor sensitivity and prevent unspecific binding from biological material and error from geometrical difference. A proof-of-concept is conducted on the integrated optics by detecting protein transglutaminase (tTG) specifically binding calcium ion (Ca 2+ ) via the finite-element method. The minimum decrease of biolayer thickness (δ a = 0.5 nm) caused by tTG-Ca 2+ interaction is much smaller than a single protein molecule (normally 1-100 nm). Associated with biolayer thickness and density, a thin dense layer is formed as Ca 2+ binds to the tTG protein. Thus, the tTG protein undergoing conformational change on binding Ca 2+ is traced and verified as mo
Who reads Design of an Integrated Optics for Transglutaminase Conformational Change?
It is typically read by researchers, students, and practitioners in Engineering.
- Author
- Chen Chen; Xun Hou; Jinhai Si
- Publisher
- Walter de Gruyter GmbH & Co. KG; Walter de Gruyter GmbH (ISSN 2191-9089)
- Published
- 2018
- Language
- EN
- Field
- Engineering (Physical Sciences)