Opening book details…
Can I read Dentate Gyrus and Hilus Transection Blocks Seizure Propagation and Granule Cell Dispersion in a Mouse Model for Mesial Temporal Lobe Epilepsy on EtoBox?
Dentate Gyrus and Hilus Transection Blocks Seizure Propagation and Granule Cell Dispersion in a Mouse Model for Mesial Temporal Lobe Epilepsy by Johan Pallud; Ute Häussler; Mélanie Langlois; Sophie Hamelin; Bertrand Devaux; Colin Deransart; Antoine Depaulis is a Neuroscience article available to read on EtoBox.
What is Dentate Gyrus and Hilus Transection Blocks Seizure Propagation and Granule Cell Dispersion in a Mouse Model for Mesial Temporal Lobe Epilepsy about?
## Abstract Epilepsy‐associated changes of the anatomical organization of the dentate gyrus and hilus may play a critical role in the initiation and propagation of seizures in mesial temporal lobe epilepsy (MTLE). This study evaluated the role of longitudinal projections in the propagation of hippocampal paroxysmal discharges (HPD) in dorsal hippocampus by performing a selective transection in a mouse model for MTLE obtained by a single unilateral intrahippocampal injection of kainic acid (KA). Full transections of the dentate gyrus and hilus were performed in the transverse axis at 22 days after KA injection when spontaneous HPD were fully developed. They: (i) significantly reduced the occurrence of HPD; (ii) increased their duration at the KA injection site; (iii) abolished their spread along the longitudinal axis of the hippocampal formation and; (iv) limited granule cell dispersion (GCD) of the dentate gyrus posterior to the transection. These data suggest that: (i) longitudinal projections through the dentate gyrus and hilus are involved in HPD spread; (ii) distant hippocampal circuits participate in the generation and cessation of HPD and; (iii) GCD requires continuous HPD to
Who reads Dentate Gyrus and Hilus Transection Blocks Seizure Propagation and Granule Cell Dispersion in a Mouse Model for Mesial Temporal Lobe Epilepsy?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Johan Pallud; Ute Häussler; Mélanie Langlois; Sophie Hamelin; Bertrand Devaux; Colin Deransart; Antoine Depaulis
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1050-9631)
- Published
- 2011
- Language
- EN
- Field
- Neuroscience (Life Sciences)