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Development of S4A–BSA–Au NPs for enhanced anti-tumor therapy of canine breast cancer† by Chen, Qi (author);Xu, Chengfang (author);Sun, Zhonghao (author);Yang, Jingjing (author);Chen, Fan (author);Lin, Zixiang (author);Lin, Degui (author);Jiang, Yanyan (author);Lin, Jiahao (author) is a Materials Science article available to read on EtoBox.

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S4A ((1__R__,2__R__,3__S__)-1,2-propanediol acetal-zeylenone) is one of the derivatives of zeylenone and exhibits superior cytotoxicity against the canine breast cancer cell line CIPp. However, its poor aqueous solubility and toxicity to normal tissue limit its clinical application. Therefore, in order to enhance the anticancer effect of S4A, in this article, BSA/BSA–Au-nanocluster-aggregated core/shell nanoparticles (B-BANC-NPs) were prepared by using bovine serum albumin (BSA) and HAuCl~4~, and then we further synthesized S4A–BSA–Au NPs which were spherical, with a diameter of about 60 nm. __In vitro__ cytotoxicity assessed by using CCK-8 assay demonstrated that the IC~50~ value of the S4A–BSA–Au NPs was 10.39 μg mL^−1^, which was not significantly different from that of S4A (10.45 μg mL^−1^). __In vitro__ apoptosis assay showed that the apoptosis rate of cells treated with S4A–BSA–Au NPs was 20.12%, which was significantly higher than that of the control group treated with S4A (11.3%). Notably, S4A–BSA–Au NPs were shown to effectively accumulate at tumor sites with fluorescence tracing. Besides, the effect of S4A–BSA–Au NPs on SPARC expression was determined by western blotting,

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Author

Chen, Qi (author);Xu, Chengfang (author);Sun, Zhonghao (author);Yang, Jingjing (author);Chen, Fan (author);Lin, Zixiang (author);Lin, Degui (author);Jiang, Yanyan (author);Lin, Jiahao (author)

Publisher

Royal Society of Chemistry (RSC)

Published

2022

Language

EN

Field

Materials Science (Physical Sciences)