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Interleukin‐6 modulates production of T lymphocyte–derived cytokines in antigen‐induced arthritis and drives inflammation‐induced osteoclastogenesis by Peter K. K. Wong; Julian M. W. Quinn; Natalie A. Sims; Annemarie van Nieuwenhuijze; Ian K. Campbell; Ian P. Wicks is a Medicine article available to read on EtoBox.
What is Interleukin‐6 modulates production of T lymphocyte–derived cytokines in antigen‐induced arthritis and drives inflammation‐induced osteoclastogenesis about?
## Abstract ## Objective To determine the cellular mediators of antigen‐induced arthritis (AIA) and the relative contribution of members of the interleukin‐6 (IL‐6) family and tumor necrosis factor (TNF) in AIA. ## Methods AIA was induced in mice deficient in T and B lymphocytes, IL‐6 (IL‐6^−/−^), TNF (TNF^−/−^), IL‐11 receptor, and oncostatin M receptor, by immunization with methylated bovine serum albumin (mBSA) followed 7 days later by intraarticular injection of mBSA. Arthritis severity was assessed histologically, and T lymphocyte responses were assessed in vitro. Anti‐TNF neutralizing antibody was administered to wild‐type mice during AIA. Bone marrow osteoclasts were generated in vitro via culture with RANKL and macrophage colony‐stimulating factor. ## Results AIA was dependent on CD4+ T lymphocytes, but not CD8+ T lymphocytes or B cells. IL‐6^−/−^ mice had reduced AIA severity and fewer osteoclasts at sites of bone erosion. This protective effect was not seen with a deficiency of other IL‐6 family members and was similar to that in TNF^−/−^ mice or wild‐type mice receiving TNF blockade treatment. IL‐6^−/−^ CD4+ T lymphocytes from draining lymph nodes had reduced antigen‐ind
Who reads Interleukin‐6 modulates production of T lymphocyte–derived cytokines in antigen‐induced arthritis and drives inflammation‐induced osteoclastogenesis?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Peter K. K. Wong; Julian M. W. Quinn; Natalie A. Sims; Annemarie van Nieuwenhuijze; Ian K. Campbell; Ian P. Wicks
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0004-3591)
- Published
- 2005
- Language
- EN
- Field
- Medicine (Health Sciences)