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Dynamic changes in microtubule configuration correlate with nuclear migration in the preblastoderm Drosophila embryo by J Baker; WE Theurkauf; G Schubiger is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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Drosophila embryogenesis is initiated by a series of syncytial mitotic divisions. The first nine of these divisions are internal, and are accompanied by two temporally distinct nuclear movements that lead to the formation of a syncytial blastoderm with a uniform monolayer of cortical nuclei. The first of these movements, which we term axial expansion, occurs during division cycles 4-6 and distributes nuclei in a hollow ellipsoid underlying the cortex. This is followed by cortical migration, during cycles 7-10, which places the nuclei in a uniform monolayer at the cortex. Here we report that these two movements differ in their geometry, velocity, cell-cycle dependence, and protein synthesis requirement. We therefore conclude that axial expansion and cortical migration are mechanistically distinct, amplifying a similar conclusion based on pharmacological data (Zalokar and Erk, 1976). We have examined microtubule organization during cortical migration and find that a network of interdigitating microtubules connects the migrating nuclei. These anti-parallel microtubule arrays are observed between migrating nuclei and yolk nuclei located deeper in the embryo. These arrays are present du

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Author

J Baker; WE Theurkauf; G Schubiger

Publisher

The Rockefeller University Press

Published

1993

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)