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A Pilot Study of Dynamic 18F-DCFPyL PET/CT Imaging of Prostate Adenocarcinoma in High-Risk Primary Prostate Cancer Patients by Michelle Lu; Liza Lindenberg; Esther Mena; Baris Turkbey; Jurgen Seidel; Anita Ton; Yolanda McKinney; Philip Eclarinal; Maria Merino; Peter Pinto; Peter Choyke; Stephen Adler is a Medicine article available to read on EtoBox.

What is A Pilot Study of Dynamic 18F-DCFPyL PET/CT Imaging of Prostate Adenocarcinoma in High-Risk Primary Prostate Cancer Patients about?

Purpose: The primary aim of this study was to investigate the pharmacokinetics of 18 F-DCFPyL, an 18 F-labeled PSMA-based ligand, and to explore the utility of early time point positron emission tomography (PET) imaging extracted from PET data to distinguish malignant primary prostate from benign prostate tissue. Procedures: Ten consecutive patients with biopsy-proven high-risk prostate cancer underwent a dynamic 18 F-DCFPyL PET/CT scan of the pelvis for the first 45 min post-injection (p.i.) followed by a static PET/CT at 2 h p.i. 18 F-DCFPyL uptake values and kinetics were compared between benign prostate tissue and prostate cancer, including quantitative pharmacokinetic PET parameters extracted from 18 F-DCFPyL time activity curves generated from dynamic data using a two-tissue compartment model and Patlak plots. Results: 18 F-DCFPyL uptake values were significantly higher in primary prostate tumors than those in benign prostatic hyperplasia (BPH) and normal prostate tissue at 5 min, 30 min, and 120 min p.i. (P = 0.0002), when examining both SUV max and SUV mean values. The two-tissue compartment model found an overall influx value (K i ) of 0.063 in primary prostate cancer, dem

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Author

Michelle Lu; Liza Lindenberg; Esther Mena; Baris Turkbey; Jurgen Seidel; Anita Ton; Yolanda McKinney; Philip Eclarinal; Maria Merino; Peter Pinto; Peter Choyke; Stephen Adler

Publisher

Springer Science and Business Media LLC

Published

2021

Language

EN

Field

Medicine (Health Sciences)