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Vocal cord paralysis secondary to vincristine treatment in children: A case series of seven children and literature review by Joanna Godbehere; Jeanette Payne; Ravi Thevasagayam is a Medicine article available to read on EtoBox.

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Vincristine is a vinca alkaloid chemotherapy agent used in the treatment of haematological malignancies including acute lymphoblastic leukaemia (ALL) and some lymphomas. Common toxicity includes neuropathy which can be peripheral, autonomic or less commonly central. 1 Vincristine remains an essential chemotherapy agent in modern ALL protocols. [1][2][3] Its mechanism of action is by inhibiting the M phase of mitosis by binding with the protein component of microtubules. Axonal degeneration takes place when axonal transport and secretory functions are impaired thus leading to apoptosis and toxicity in neural tissue. This is typically seen within the extra-ocular muscles and larynx in cranial neuropathy. 1 Recurrent laryngeal nerve palsy resulting in vocal cord paralysis (vcp) in children has been documented in the literature in multiple case reports and small number of case series. 4 We present the largest case series to date of seven children who sustained vcp secondary to vincristine chemotherapy for ALL and review the literature. ### 1.1 | Ethical considerations Ethical approval was not required by our hospital trust. ## 2 | ME THODS A retrospective case note review was performed

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Author

Joanna Godbehere; Jeanette Payne; Ravi Thevasagayam

Publisher

Wiley

Published

2021

Language

EN

Field

Medicine (Health Sciences)