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Phase Separation in Biology and Disease by Richard W. Kriwacki, Julie D. Forman-Kay, Geraldine Seydoux is a nonfiction available to read on EtoBox.

What is Phase Separation in Biology and Disease about?

It has long been appreciated that cells contain microenvironments not enclosed by membranes. In a classic study [1], Wilson concluded that the cytoplasm of star fish and sea urchin eggs “is a mixture of liquids in the form of a fine emulsion consisting of a continuous substance in which are suspended drops.” More than 100 years later, the concept of the cytoplasm as an emulsion is enjoying a revival, as several nuclear and cytoplasmic bodies have been reported to exhibit liquid-like characteristics: round shape, permeable surface, dynamic internal components, and ability to flow, drip, and fuse [2], [3], [4], [5]. These include P granules and other germ granules, stress granules, and P-bodies in the cytosol and nucleoli, paraspeckles, Cajal bodies, and PML bodies in the nucleus [6]. It is now appreciated that these membrane-less, fluid structures form through liquid–liquid phase separation of their components [4], [5], [7], often including proteins and nucleic acids, especially RNA. However, more recently, the process of phase separation has been associated with many additional, diverse biological structures including signaling centers formed by trans-membrane receptors [8], membra

Who reads Phase Separation in Biology and Disease?

Author

Richard W. Kriwacki, Julie D. Forman-Kay, Geraldine Seydoux

Publisher

Elsevier

Published

2018

Language

EN

Category

nonfiction

Subjects

Science, Biology, Stem