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CRISPR Platform for BDW568 Target ID by xiaolingshawn123 is a document available to read on EtoBox.

What is CRISPR Platform for BDW568 Target ID about?

The article presents a novel CRISPR-based platform for identifying cellular targets of small molecules, specifically focusing on BDW568, a type-I interferon signaling activator. The platform utilizes a selection system linked to a suicide gene, allowing for the enrichment of cells with knocked-out target genes, which were then sequenced to reveal the identities of the drug targets. The study successfully identified STING as the target of BDW568 and CES1 as a key enzyme necessary for its activation, demonstr

Author

xiaolingshawn123

Language

EN