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Acetaminophen is a common pain reliever that can cause liver injury when taken in high doses due to its metabolism by cytochrome P-450 enzymes. Overdose during pregnancy has been associated with fetal death. It is rapidly absorbed and eliminated mainly through the liver, with a therapeutic half-life of 1-3 hours that may be longer after overdose. Toxic doses are more than 200 mg/kg in children or 6-7 g in adults. Treatment is supportive and focused on managing symptoms of toxicity.

Author

Ayu Dewi

Language

EN