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Brain Atrophy Is Associated with Disability Progression in Patients with MS followed in a Clinical Routine by E. Ghione; N. Bergsland; M.G. Dwyer; J. Hagemeier; D. Jakimovski; I. Paunkoski; D.P. Ramasamy; D. Silva; E. Carl; D. Hojnacki; C. Kolb; B. Weinstock-Guttman; R. Zivadinov is a Medicine article available to read on EtoBox.
What is Brain Atrophy Is Associated with Disability Progression in Patients with MS followed in a Clinical Routine about?
## BACKGROUND AND PURPOSE: The assessment of brain atrophy in a clinical routine is not performed routinely in multiple sclerosis. Our aim was to determine the feasibility of brain atrophy measurement and its association with disability progression in patients with MS followed in a clinical routine for 5 years. ## Methods : A total of 1815 subjects, 1514 with MS and 137 with clinically isolated syndrome and 164 healthy individuals, were collected retrospectively. Of 11,794 MR imaging brain scans included in the analysis, 8423 MRIs were performed on a 3T, and 3371 MRIs, on a 1.5T scanner. All patients underwent 3D T1WI and T2-FLAIR examinations at all time points of the study. Whole-brain volume changes were measured by percentage brain volume change/normalized brain volume change using SIENA/SIENAX on 3D T1WI and percentage lateral ventricle volume change using NeuroSTREAM on T2-FLAIR. RESULTS: Percentage brain volume change failed in 36.7% of the subjects; percentage normalized brain volume change, in 19.2%; and percentage lateral ventricle volume change, in 3.3% because of protocol changes, poor scan quality, artifacts, and anatomic variations. Annualized brain volume changes wer
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- Author
- E. Ghione; N. Bergsland; M.G. Dwyer; J. Hagemeier; D. Jakimovski; I. Paunkoski; D.P. Ramasamy; D. Silva; E. Carl; D. Hojnacki; C. Kolb; B. Weinstock-Guttman; R. Zivadinov
- Publisher
- American Society of Neuroradiology; American Society of Neuoradiology; American Society of Neuroradiology (ASNR) (ISSN 0195-6108)
- Published
- 2018
- Language
- EN
- Field
- Medicine (Health Sciences)