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This study investigated the effects of synthetic matrix metalloproteinase (MMP) inhibitors on collagen gel contraction and gene expression by periodontal ligament cells. The inhibitors reduced gel contraction by 20-80% compared to controls by inhibiting MMP activity. Specifically, CMT-3 and doxycycline most strongly reduced contraction and also decreased mRNA expression of MMP-2, MMP-3, and α-smooth muscle actin. While MMP expression was reduced, the inhibitors did not affect levels of MMPs or tissue inhibi

Author

Nur Sri Wahyuni

Language

EN