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Vasopressin Gene Expression in Rats with Experimental Cirrhosis by DR. Jin K. Kim; Sandra N. Summer; Randy L. Howard; Robert W. Schrier is a Medicine article available to read on EtoBox.

What is Vasopressin Gene Expression in Rats with Experimental Cirrhosis about?

Impaired ability to excrete a water load occurs in a substantial number of patients with advanced cirrhosis and in animals with experimental cirrhosis. The nonosmotic stimulation of arginine vasopressin release from the pituitary has been implicated as an important factor in the abnormal water excretion in patients and animals with cirrhosis. In this study, arginine vasopressin hypothalamic gene expression was studied in cirrhotic rats. Cirrhosis was induced by a combination of phenobarbital treatment in drinking water and weekly intragastric administration of carbon tetrachloride for 13 to 15 wk. Severe cirrhosis was confirmed by morphological analysis and the presence of ascites. Plasma arginine vasopressin was also significantly higher in rats with cirrhosis (control = 1.77 f 0.16 and cirrhotic rats = 4.14 ? 0.62 pglml, n = 9, p < 0.002). Hypothalamic arginine vasopressin messenger RNA was also significantly higher in cirrhotic rats (control = 762.1 +. 132.3 and cirrhotic rats = 1,834.2 f 271.9 pflypothalamus, n = 9, p < 0.005). Pituitary arginine vasopressin content was significantly lowered in cirrhotic rats (control = 3.69 f 0.98 and cirrhotic rats = 1.57 f 0.09 pg/pituitary,

Who reads Vasopressin Gene Expression in Rats with Experimental Cirrhosis?

Author

DR. Jin K. Kim; Sandra N. Summer; Randy L. Howard; Robert W. Schrier

Publisher

Ovid Technologies (Wolters Kluwer Health)

Published

1993

Language

EN

Field

Medicine (Health Sciences)