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Polyethylenimine‐mediated PUMA gene delivery to orthotopic oral cancer: Suppression of tumor growth through apoptosis induction in situ and prolonged survival by Cheng‐Chang Yeh; Hsiao‐Ling Hsieh; Jihjong Lee; Yi‐Hua Jan; Tsung‐Ching Lai; Chi‐Yuan Hong; Michael Hsiao; Mark Y. P. Kuo is a Medicine article available to read on EtoBox.
What is Polyethylenimine‐mediated PUMA gene delivery to orthotopic oral cancer: Suppression of tumor growth through apoptosis induction in situ and prolonged survival about?
## Abstract ## Background. PUMA (a p53 up‐regulated modulator of apoptosis) is induced by p53 tumor suppressor and other apoptotic stimuli. It was found to be a principal mediator of cell death in response to diverse apoptotic signals, implicating PUMA as a likely tumor suppressor. ## Methods. In this study, we examined the efficacy of targeted PUMA gene therapy in human oral cancer (SAS) cells using polyethylenimine (PEI)‐mediated transfection for gene delivery. ## Results. Exogenous expression of PUMA in SAS cells resulted in apoptosis with cytochrome c release, activation of caspase‐3 and ‐9, and cleavage of PARP. Gene delivery of PEI/PUMA in SAS xenografts induced apoptosis and resulted in significant reductions (∼60%) of tumor growth in vivo. Furthermore, we have shown that PEI‐mediated PUMA gene therapy prolonged survival of animals with orthotopic SAS oral cancers. ## Conclusions. Taken together, these results indicated that PUMA gene therapy via PEI delivery could be a promising method for the treatment of oral squamous cell carcinoma. © 2010 Wiley Periodicals, Inc. Head Neck, 2011
Who reads Polyethylenimine‐mediated PUMA gene delivery to orthotopic oral cancer: Suppression of tumor growth through apoptosis induction in situ and prolonged survival?
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- Author
- Cheng‐Chang Yeh; Hsiao‐Ling Hsieh; Jihjong Lee; Yi‐Hua Jan; Tsung‐Ching Lai; Chi‐Yuan Hong; Michael Hsiao; Mark Y. P. Kuo
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 1043-3074)
- Published
- 2010
- Language
- EN
- Field
- Medicine (Health Sciences)