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Constant Rate Infusion of Vancomycin in Premature Neonates: a New Dosage Schedule by F. Pawlotsky; A. Thomas; M. F. Kergueris; T. Debillon; J. C. Roze is a Medicine article available to read on EtoBox.

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__Aims__ Since vancomycin's bactericidal action has been shown to be time‐dependent, a constant rate infusion over 24 h might result in a better bactericidal efficacy. The purpose of this study was to define a new dosage schedule in prematures. __Methods__ Two vancomycin 24 h constant rate infusion schedules were tested in two groups of neonates. Postconceptional age (PCA) was 27 to 41 weeks in group 1 (__n__=24) and 28 to 51.5 weeks in group 2 (__n__=29). Group 1 neonates received continuous infusion of 10 to 30 mg kg^−1^ day^−1^, adjusted for PCA and weight. Group 2 was designed to take into account the significant relationship observed in group 1 between vancomycin clearance standardized on weight and PCA and consisted of a constant loading dose of 7 mg kg^−1^ followed by continuous infusion of 10 to 40 mg kg^−1^ day^−1^ adjusted for PCA and weight. __Results__ Mean vancomycin serum concentration at steady state was 11±3.1 mg l^−1^ in group 1 and 15.4±6.2 mg l^−1^ in group 2. Fifty‐six percent of group 1 values __vs__ 88% of group 2 values were between 10 and 30 mg l^−1^ at steady state (__P__<0.01). Both regimens were well tolerated. __Conclusion__ A loading dose of vancomycin

Who reads Constant Rate Infusion of Vancomycin in Premature Neonates: a New Dosage Schedule?

Author

F. Pawlotsky; A. Thomas; M. F. Kergueris; T. Debillon; J. C. Roze

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley; Research Square (ISSN 0306-5251)

Published

1998

Language

EN

Field

Medicine (Health Sciences)