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Viral suppression in the era of transition to dolutegravir-based therapy in Cameroon: Children at high risk of virological failure due to the lowly transition in pediatrics by Joseph Fokam; Alex Durand Nka; Flore Yollande Mamgue Dzukam; Jeremiah Efakika Gabisa; Yagai Bouba; Michel Carlos Tommo Tchouaket; Aude Christelle Ka’e; Ezechiel Ngoufack Jagni Semengue; Desire Takou; Sylvie Moudourou; Nadine Fainguem; Willy Pabo; Rachel Audrey Nayang Mundo; Aurelie Minelle Kengni Ngueko; Collins Ambe Chenwi; Junie Flore Yimga; Marie Krystel Nnomo Zam; Rachel Simo Kamgaing; Charlotte Tangimpundu; Nelly Kamgaing; Anne-Esther Njom-Nlend; Paul Ndombo Koki; Daniel Kesseng; Suzie Ndiang Tetang; Etienne Kembou; Lifanda Ebiama Lifanda; Bouba Pamen; Alice Ketchaji; Edith Saounde Temgoua; Serge Clotaire Billong; Anne-Cecile Zoung-Kanyi Bissek; Hamsatou Hadja; Edie Gregory Halle; Vittorio Colizzi; Carlo-Federico Perno; Samuel Martin Sosso; Alexis Ndjolo is a Medicine article available to read on EtoBox.

What is Viral suppression in the era of transition to dolutegravir-based therapy in Cameroon: Children at high risk of virological failure due to the lowly transition in pediatrics about?

This study aimed to compare viral suppression (VS) between children, adolescents, and adults in the frame of transition to dolutegravir (DTG)-based antiretroviral therapy (ART) in the Cameroonian context. A comparative cross-sectional study was conducted from January 2021 through May 2022 amongst ART-experienced patients received at the Chantal BIYA International Reference Centre in Yaounde-Cameroon, for viral load (VL) monitoring. VS was defined as VL < 1000 copies/mL and viral undetectability as VL < 50 copies/mL. Chi-square and multivariate binary logistic regression models were used to identify factors associated with VS. Data were analyzed using SPSS v.20.0 (SPSS Inc., Chicago, Illinois), with __P__ < .05 considered significant. A total of 9034 patients (72.2% females) were enrolled. In all, there were 8585 (95.0%) adults, 227 (2.5%) adolescents, and 222 (2.5%) children; 1627 (18.0%) were on non-nucleoside reverse transcriptase-based, 290 (3.2%) on PI-based, and 7117 (78.8%) on DTG-based ART. Of those on DTG-based ART, only 82 (1.2%) were children, 138 (1.9%) adolescents, and 6897 (96.9%) adults. Median (interquartile range) duration on ART was 24 (12–72) months (24 months on

Who reads Viral suppression in the era of transition to dolutegravir-based therapy in Cameroon: Children at high risk of virological failure due to the lowly transition in pediatrics?

Author

Joseph Fokam; Alex Durand Nka; Flore Yollande Mamgue Dzukam; Jeremiah Efakika Gabisa; Yagai Bouba; Michel Carlos Tommo Tchouaket; Aude Christelle Ka’e; Ezechiel Ngoufack Jagni Semengue; Desire Takou; Sylvie Moudourou; Nadine Fainguem; Willy Pabo; Rachel Audrey Nayang Mundo; Aurelie Minelle Kengni Ngueko; Collins Ambe Chenwi; Junie Flore Yimga; Marie Krystel Nnomo Zam; Rachel Simo Kamgaing; Charlotte Tangimpundu; Nelly Kamgaing; Anne-Esther Njom-Nlend; Paul Ndombo Koki; Daniel Kesseng; Suzie Ndiang Tetang; Etienne Kembou; Lifanda Ebiama Lifanda; Bouba Pamen; Alice Ketchaji; Edith Saounde Temgoua; Serge Clotaire Billong; Anne-Cecile Zoung-Kanyi Bissek; Hamsatou Hadja; Edie Gregory Halle; Vittorio Colizzi; Carlo-Federico Perno; Samuel Martin Sosso; Alexis Ndjolo

Publisher

Ovid Technologies (Wolters Kluwer Health)

Published

2023

Language

EN

Field

Medicine (Health Sciences)