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Effect of Immunomodulatory Supplements Based on Echinacea Angustifolia and Echinacea Purpurea on the Posttreatment Relapse Incidence of Genital Condylomatosis: A Prospective Randomized Study by Nicoletta De Rosa; Pierluigi Giampaolino; Giada Lavitola; Ilaria Morra; Carmen Formisano; Carmine Nappi; Giuseppe Bifulco is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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__Introduction.__HPV infection is a highly infectious disease; about 65% of partners of individuals with genital warts will develop genital condylomatosis. Only in 20-30% it regresses spontaneously and relapse rates range deeply (9-80%). Echinacea extracts possess antiviral and immunomodulator activities. The aim of this study was to evaluate the efficacy of the therapy, using a formulation based on HPVADL18® (on dry extracts of 200 mg Echinacea Purpurea (EP) roots plus E. Angustifolia (EA)), on the posttreatment relapse incidence of genital condylomatosis.__Materials and Methods.__It is a prospective single-arm study. Patients with a satisfactory and positive vulvoscopy, colposcopy, or peniscopy for genital condylomatosis were divided into two random groups and subjected to destructive therapy with Co2 Laser. Group A (N=64) immediately after the laser therapy started a 4-month treatment with oral HPVADL18®; Group B (N=61) did not undergo any additional therapy. Patients were subjected to a follow-up after 1, 6, and 12 months. Differences in relapse incidence between the two groups during follow-up controls were evaluated by__χ__2-test; the groups were stratified by age, gender, an

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Author

Nicoletta De Rosa; Pierluigi Giampaolino; Giada Lavitola; Ilaria Morra; Carmen Formisano; Carmine Nappi; Giuseppe Bifulco

Publisher

Hindawi Limited; Hindawi Publishing Corporation (ISSN 2314-6133)

Published

2019

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)