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## Abstract ## Objective To assess whether nonsurgical therapies were related with clearance of cervical infection of high‐risk human papilloma virus (hr‐HPV) or regression of mild abnormal cytology related with hr‐HPV. ## Methods Until March 2023, we identified a total of 10 424 women with cervical infection of hr‐HPV and 1966 women with mild abnormal cytology related with hr‐HPV from 44 studies that met the inclusion criteria. ## Results After systematically retrieving literature, we identified 2317 citations and 44 randomized controlled studies (RCT) were enrolled. Cumulative results suggested women with cervical infection of hr‐HPV might benefit from nonsurgical therapies. Both the clearance of hr‐HPV (OR: 3.83, I^2^ = 99%, p < 0.00001) and regression of mild abnormal cytology related with hr‐HPV (OR: 3.12, I^2^ = 63%, p < 0.00001) were significantly higher than control group. Subgroup analysis stratified by systematic therapy, topical therapy, traditional Chinese medicines (TCMs), and presistent hr‐HPV got consistent results. There was substantial heterogeneity between trials (I^2^ = 87% for clearance of hr‐HPV and 63% for regression of cytology), sensitivity analysis was perf

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Author

Yuan Zhuang; Hua Yang

Publisher

Wiley

Published

2023

Language

EN

Field

Medicine (Health Sciences)