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Can I read A Nucleophilic Deprotection of Carbamate Mediated by 2-Mercaptoethanol on EtoBox?
A Nucleophilic Deprotection of Carbamate Mediated by 2-Mercaptoethanol by Thomas Scattolin; Tawfik Gharbaoui; Cheng-yi Chen is a Chemistry article available to read on EtoBox.
What is A Nucleophilic Deprotection of Carbamate Mediated by 2-Mercaptoethanol about?
Carbamates, typically used for the protection of amines, including Cbz, Alloc, and methyl carbamate, can be readily deprotected by treatment with 2-mercaptoethanol in the presence of potassium phosphate tribasic in ,-dimethylacetamide at 75 °C. This nucleophilic deprotection protocol is superior to the standard hydrogenolysis or Lewis acid-mediated deprotection conditions for substrates bearing a functionality sensitive to these more traditional methods.
Who reads A Nucleophilic Deprotection of Carbamate Mediated by 2-Mercaptoethanol?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Thomas Scattolin; Tawfik Gharbaoui; Cheng-yi Chen
- Published
- 2022
- Language
- EN
- Field
- Chemistry (Physical Sciences)
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