Opening book details…
Can I read Corneal Kindling in Mice: Behavioral and Pharmacological Differences to Conventional Kindling on EtoBox?
Corneal Kindling in Mice: Behavioral and Pharmacological Differences to Conventional Kindling by Heidrun Potschka; Wolfgang Löscher is a Medicine article available to read on EtoBox.
What is Corneal Kindling in Mice: Behavioral and Pharmacological Differences to Conventional Kindling about?
Electrical kindling via unilateral implanted depth electrodes in rats is currently the most commonly used model for temporal lobe epilepsy, but the use of this model in drug screening for the identification of novel anticonvulsants is markedly hampered by the laborious and time-consuming preparation and the size of the animals. Kindling of male mice via transcorneal electrical stimulation has recently proposed as a cost-effective screening model that may improve the preclinical evaluation of efficacy and adverse effect potential of drug candidates for treatment of partial epilepsy. In the present study, corneal kindling was characterized and compared in male and female mice. In fully kindled mice, the anticonvulsant efficacy of the standard antiepileptic drug phenytoin was determined. Large groups of kindled mice were used to examine whether phenytoin non-responders can be selected in the corneal kindling model as reported previously for amygdala kindling. Furthermore, in view of the enhanced adverse effect potential of NMDA antagonists in amygdala kindled rats, it was evaluated whether corneally kindled mice also differ in this respect from non-kindled animals. Mice of both gender
Who reads Corneal Kindling in Mice: Behavioral and Pharmacological Differences to Conventional Kindling?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Heidrun Potschka; Wolfgang Löscher
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0920-1211)
- Published
- 1999
- Language
- EN
- Field
- Medicine (Health Sciences)