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Can I read Presence and regulation of transforming growth factor beta mRNA and protein in the normal and lesioned rat sciatic nerve on EtoBox?
Presence and regulation of transforming growth factor beta mRNA and protein in the normal and lesioned rat sciatic nerve by Dr. M. Rufer; K. Flanders; K. Unsicker is a Neuroscience article available to read on EtoBox.
What is Presence and regulation of transforming growth factor beta mRNA and protein in the normal and lesioned rat sciatic nerve about?
The transforming growth factors beta (TGF-P), a family of regulatory polypeptides, are involved in numerous vital processes including inflammation and wound healing. Since repair of a peripheral nerve lesion includes a series of well-defined steps of cellular actions possibly controlled by TGF-Ps, and since TGF-P mRNA and immunoreactivity have been found in the normal peripheral nerve, we have examined TGF-P mRNA regulation and protein expression in the lesioned peripheral nerve. Sciatic nerves of adult rats were either crushed (allowing axonal regeneration) or transected (to prevent axonal regeneration and to induce Wallerian degeneration in the distal stump). After intervals of 6 hours, 2 and 6 days post-lesion, the rats were sacrificed and each nerve was cut into four segments, two proximal and two distal to the lesion site. TGF-P1-3 mRNA were determined for each segment. We demonstrate that TGF-P1 mRNA levels are higher than those of TGF-P3; the amplitude of mRNA regulation depends on time, type of lesion and localization relative to the lesion site. TGF-P2 mRNA could not be detected. For TGF-P1-3 immunocytochemistry , animals were sacrificed 12, 24, 48, 72 hours and 7 and 14 d
Who reads Presence and regulation of transforming growth factor beta mRNA and protein in the normal and lesioned rat sciatic nerve?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Dr. M. Rufer; K. Flanders; K. Unsicker
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0360-4012)
- Published
- 1994
- Language
- EN
- Field
- Neuroscience (Life Sciences)