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Can I read Spongostan^TM^ Leads to Increased Regeneration of a Rat Calvarial Critical Size Defect Compared to NanoBone^®^ and Actifuse on EtoBox?
Spongostan^TM^ Leads to Increased Regeneration of a Rat Calvarial Critical Size Defect Compared to NanoBone^®^ and Actifuse by Wähnert, Dirk (author);Koettnitz, Julian (author);Merten, Madlen (author);Kronenberg, Daniel (author);Stange, Richard (author);Greiner, Johannes F. W. (author);Kaltschmidt, Christian (author);Vordemvenne, Thomas (author);Kaltschmidt, Barbara (author) is a Engineering article available to read on EtoBox.
What is Spongostan^TM^ Leads to Increased Regeneration of a Rat Calvarial Critical Size Defect Compared to NanoBone^®^ and Actifuse about?
Bone substitute materials are becoming increasingly important in oral and maxillofacial surgery. Reconstruction of critical size bone defects is still challenging for surgeons. Here, we compared the clinically applied organic bone substitute materials NanoBone^®^ (nanocrystalline hydroxyapatite and nanostructured silica gel; __n__ = 5) and Actifuse (calcium phosphate with silicate substitution; __n__ = 5) with natural collagen-based SpongostanTM (hardened pork gelatin containing formalin and lauryl alcohol; __n__ = 5) in bilateral rat critical-size defects (5 mm diameter). On topological level, NanoBone is known to harbour nanopores of about 20 nm diameter, while Actifuse comprises micropores of 200–500 μm. SpongostanTM, which is clinically applied as a haemostatic agent, combines in its wet form both nano- and microporous topological features by comprising 60.66 ± 24.48 μm micropores accompanied by nanopores of 32.97 ± 1.41 nm diameter. Micro-computed tomography (μCT) used for evaluation 30 days after surgery revealed a significant increase in bone volume by all three bone substitute materials in comparison to the untreated controls. Clearly visual was the closure of trepanation i
Who reads Spongostan^TM^ Leads to Increased Regeneration of a Rat Calvarial Critical Size Defect Compared to NanoBone^®^ and Actifuse?
It is typically read by researchers, students, and practitioners in Engineering.
- Author
- Wähnert, Dirk (author);Koettnitz, Julian (author);Merten, Madlen (author);Kronenberg, Daniel (author);Stange, Richard (author);Greiner, Johannes F. W. (author);Kaltschmidt, Christian (author);Vordemvenne, Thomas (author);Kaltschmidt, Barbara (author)
- Publisher
- MDPI AG
- Published
- 2021
- Language
- EN
- Field
- Engineering (Physical Sciences)