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KRAS G12D or G12V Mutation in Human Brain Arteriovenous Malformations by Mieko Oka; Mika Kushamae; Tomohiro Aoki; Tadashi Yamaguchi; Keiko Kitazato; Yu Abekura; Takakazu Kawamata; Tohru Mizutani; Susumu Miyamoto; Yasushi Takagi is a Medicine article available to read on EtoBox.

What is KRAS G12D or G12V Mutation in Human Brain Arteriovenous Malformations about?

## Background: Brain arteriovenous malformations (bavms) are vascular malformations composed of tangles of abnormally developed vasculature without capillaries. abnormal shunting of arteries and veins is formed, resulting in high-pressure vascular channels, which potentially lead to rupture. bavms are generally considered a congenital disorder. but clinical evidence regarding involution, regrowth, and de novo formation argue against the static condition of this disease. recently, the presence of the somatic activating kras mutations in more than half of bavm cases was reported, suggesting the role of kras function in the pathogenesis. ## Methods: Kras mutation in codon35 (g→a, g12d; g→t, g12v) was examined by a digital polymerase chain reaction analysis using genome purified from paraffin-embedded slides of human bavms. we also examined protein expression of kras g12d in lesions to corroborate results from digital polymerase chain reaction analysis. ## Results: We detected codon35 g→a mutation in 15 (39.5%) among 38 samples and codon35 g→t mutation in 10 (27.0%) among 37 samples we could assess mutations. there were no samples positive for both codon35 g→a and g→t mutation. the rat

Who reads KRAS G12D or G12V Mutation in Human Brain Arteriovenous Malformations?

Author

Mieko Oka; Mika Kushamae; Tomohiro Aoki; Tadashi Yamaguchi; Keiko Kitazato; Yu Abekura; Takakazu Kawamata; Tohru Mizutani; Susumu Miyamoto; Yasushi Takagi

Publisher

Elsevier ; Elsevier BV (ISSN 1878-8750)

Published

2019

Language

EN

Field

Medicine (Health Sciences)