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Phylogeographic analysis of dengue virus serotype 1 and cosmopolitan serotype 2 in Africa by Philippe Selhorst; Sebastian Lequime; Gytis Dudas; Sam Proesmans; Pascal Lutumba; Freddy Katshongo; Kadrie Ramadan; Isabel Micalessi; Steve Ahuka-Mundeke; Veerle Vanlerberghe; Marjan Van Esbroeck; Kevin K. Ariën is a Medicine article available to read on EtoBox.
What is Phylogeographic analysis of dengue virus serotype 1 and cosmopolitan serotype 2 in Africa about?
Background : The origin and spread of dengue virus (DENV) circulating in Africa remain poorly characterized, with African sequences representing <1% of global sequence data. Methods : Whole genome sequencing was performed on serum samples (n=29) from an undifferentiated fever study in 2016 in the Democratic Republic of Congo (DRC), and from febrile travelers returning from Africa. The evolutionary history of the newly acquired African DENV-1 (n=1) and Cosmopolitan genotype DENV-2 (n=18) genomes, was reconstructed using a phylogeographic, time-scaled Bayesian analysis on a curated DENV panel including all known African sequences. Results : A minimum of 10 and 8 introductions could be identified into Africa for respectively DENV-1 and Cosmopolitan DENV-2, almost all originating from Asia. Three introductions were previously unknown. The currently circulating virus comprises mainly recently introduced clades and one long-established, African clade. Robust geographical clustering suggests limited spread of DENV after each introduction. Our data identified the DRC as the source of the 2018 Angolan DENV-2 epidemic, and similarly, the 2013 Angolan DENV-1 outbreak as the origin of our DRC
Who reads Phylogeographic analysis of dengue virus serotype 1 and cosmopolitan serotype 2 in Africa?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Philippe Selhorst; Sebastian Lequime; Gytis Dudas; Sam Proesmans; Pascal Lutumba; Freddy Katshongo; Kadrie Ramadan; Isabel Micalessi; Steve Ahuka-Mundeke; Veerle Vanlerberghe; Marjan Van Esbroeck; Kevin K. Ariën
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)