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Comparison of Quantitative Results of Drugs in Human Hair By by H Sachs; I Raff is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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Until the first determination of opiates in human hair by GC/MS in 1985, radioimmunological results of hair examinations met with opposition. Since then, further GC/MS methods have been developed that have led not only to considerably increased sensitivity, but can also be used in hair analysis for screening purposes and can detect substances for which RIA kits are not available. In the present study different extraction methods were used along with two GC/MS processes which back-up each other. These methods include the enzymatic dissolution of the hair, incubation with a buffer solution followed by a solid-phase extraction and incubation with methanol without a further extraction. The GC/MS examination for heroin, cocaine, hashish and selected pharmaceuticals was carried out after derivatization with pentafluoropropionic acid anhydride or pentafluoro-1-propanol. Because of the higher sensitivity and versatility of GC/MS, two GC/MS processes were used to confirm each other instead of backing-up radioimmunological measurements with GC/MS.

Who reads Comparison of Quantitative Results of Drugs in Human Hair By?

Author

H Sachs; I Raff

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0379-0738)

Published

1993

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)