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Clinical Prognostic Markers in Patients with Severe Sepsis: a Prospective Analysis of 139 Consecutive Cases by Charalambos A Gogos; Alexandra Lekkou; Ourania Papageorgiou; Dimitrios Siagris; Athanasios Skoutelis; Harry P Bassaris is a Medicine article available to read on EtoBox.

What is Clinical Prognostic Markers in Patients with Severe Sepsis: a Prospective Analysis of 139 Consecutive Cases about?

Objectives: To analyze the clinical characteristics and determine predictive factors of mortality in previously healthy individuals suffering from severe sepsis. Methods: The study included 139 patients with severe sepsis, admitted to the Department of Medicine over a two years period. Data recorded on admission included demographic information, blood pressure, core temperature, white blood count, hepatic and renal function tests, coagulation factors, blood gases, serum lactic acid levels, simplified acute physiology score (SAPS-II) and Glasgow Coma Scale (GCS). Results: On admission, 62 patients were hypotensive, 52 had signs of diffuse intravascular coagulation (DIC), 72 had renal and 27 hepatic dysfunction. The overall mortality rate was 27.3%. Twenty-nine patients had septic shock on admission with a mortality rate of 62.07%. Hypoxemia, metabolic acidosis and the presence of DIC were more frequent in non-survivors, who also had significantly higher SAPS-II on admission and days 3 and 7. Independent factors associated with mortality were older age, septic shock, DIC and acute renal failure on admission, as well as SAPS-II at all time points and lactic acid levels on day 7. Concl

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Author

Charalambos A Gogos; Alexandra Lekkou; Ourania Papageorgiou; Dimitrios Siagris; Athanasios Skoutelis; Harry P Bassaris

Publisher

Elsevier Science; Elsevier ; W. B. Saunders Co., Ltd.; Elsevier BV (ISSN 0163-4453)

Published

2003

Language

EN

Field

Medicine (Health Sciences)