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Tissue Kallikrein and Kinins in Renal Disease by Sarala Naicker; Strini Naidoo; Reena Ramsaroop; Derseree Moodley; Kanti Bhoola is a Immunology and Microbiology article available to read on EtoBox.

What is Tissue Kallikrein and Kinins in Renal Disease about?

The renal kallikrein-kinin system is involved in sodium and water homeostasis, blood pressure regulation and inflammation. Tissue kallikrein and kinin levels were measured in the urine of patients with renal disease and in the urine of living related kidney donors prior to uninephrectomy who served as controls. Tissue kallikrein and kinin B1 and B2 receptors were immunolocalised by confocal microscopy in renal biopsy material from patients with renal disease and controls (fresh autopsy material and normal kidney tissue from nephrectomies for malignancy). Urinary tissue kallikrein excretion was significantly decreased in patients with mild renal disease (16.6 +/- 6.7 ng tissue kallikrein (TK)/ng protein; p < 0.05) and more markedly so (1.8 +/- 0.7 ng TK/microg protein; p < 0.01) in patients with severe renal failure requiring dialysis compared to normal controls (78.9 +/- 31.7 ng TK/microg protein). Basal kinin values were unchanged in patients with renal disease (14 +/- 0.8 ng/ml) compared to controls (13.3 +/- 0.56 ng/ml). In control kidney tissue kallikrein was immunolocalised in the distal connecting tubules and collecting ducts whereas decreased immunolabelling was observed wit

Who reads Tissue Kallikrein and Kinins in Renal Disease?

Author

Sarala Naicker; Strini Naidoo; Reena Ramsaroop; Derseree Moodley; Kanti Bhoola

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0162-3109)

Published

1999

Language

EN

Field

Immunology and Microbiology (Life Sciences)