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Mitochondrial Metabolic Reprogramming Induced by Calorie Restriction by Alejandro Martin-Montalvo; Rafael de Cabo is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Mitochondrial Metabolic Reprogramming Induced by Calorie Restriction about?
## Significance: Calorie restriction (cr) is a known intervention that delays most aging processes. most of the beneficial effects of cr are mediated by improved maintenance of mitochondrial performance in aged individuals. the control of mitochondrial biogenesis, apoptosis, and protein turnover is required for healthy aging. cr is able to induce molecular mechanisms that preserve oxidative capacity and decrease oxidative damage. ## Recent advances and critical issues: Published data indicate that peroxisome proliferator-activated receptor gamma coactivator 1 alpha (pgc-1α) is activated in old animals under cr conditions compared to ad libitum counterparts, enhancing mitochondrial biogenesis. molecular regulation of pgc-1α has recently attracted significant research interest. we discuss the master regulators of energy metabolism such as amp-activated protein kinase and sirtuin 1 among others that have been demonstrated to activate mitochondrial biogenesis through increased pgc-1α activity at transcriptional and post-translational levels. additionally, we describe the latest findings that explain how cr promotes mitochondrial efficiency and decreases mitochondrial-derived oxidative
Who reads Mitochondrial Metabolic Reprogramming Induced by Calorie Restriction?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Alejandro Martin-Montalvo; Rafael de Cabo
- Publisher
- Mary Ann Liebert Inc
- Published
- 2013
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)